Uplifted by love and comfort from her family, Lois (Loey), age 85 of Baldwinsville NY, passed away following a 20-year journey with multiple myeloma. Lois leaves behind many friends and family whom she loved and treasured. Following 50 years of marriage, she is predeceased by her husband, Nicholas A. DeFio, in 2012 and infant son, Paul. She is survived by her four children, Lori (Timothy) Browne, Mary Margaret (Thomas) Brotzki, Janine (Thomas) Kamide and Daniel DeFio; grandchildren Bridget (Wynn) Schoeneck, Nicholas Poorman, Caroline (Patrick) Donohue, Kelsey Poorman, Virginia (Paul) Zebari, Julia Kamide, Laura Kamide, Luke DeFio, Jack DeFio, Katie DeFio and Ella DeFio; and great-grandchildren Theodore and Robert Schoeneck, Lois Donohue and Michael Zebari. She is also survived by siblings Rita O'Brien, Larry (Jeannettie) Rocker, Rev. Stephen Rocker and Peter Rocker, Sister-in Law, Ellen DeFio and several nieces, nephews, godchildren and cousins.

Born in Port Leyden, NY, Lois graduated from Port Leyden High School followed by SUNY Canton in 1957. She raised her children and worked at the family insurance agency, Upstate Factors, Inc. Lois was a communicant of St. Augustine's Catholic Church where she served on numerous faith-filled committees over the years. Lois had a kind and friendly spirit with everyone she met and a quiet, quick wit. She loved the joy of Sunday dinners with her family, holidays, birthdays, and every type of occasion to gather together her kids, grandkids and great grandchildren. Lois inspired her family and many others with her inner strength and positive outlook. Despite life's many challenges, she was always amiable and upbeat. She said she was the luckiest person alive.

The family and Lois thank Dr. Daniel Bingham for keeping her alive for 20 years following a 3–5 year diagnosis, the most amazing and caring staff at McHarrie Pointe, where she lived since 2017, and the compassionate staff who eased her last few months at McHarrie Syracuse Home.

A calling hour will be held on Thursday, December 22 from 10:00 am–11:00 at St. Augustine's Catholic Church on O'Brien Road, Baldwinsville, NY 13027 followed by a Catholic Mass at 11:00am the same day. Burial will be at Our Lady of Peace Cemetery in Baldwinsville, NY 13027.

In lieu of flowers, donations may be made to any of Cancer Connects, 5008 Brittonfield Parkway, PO Box 2010, East Syracuse, NY 13057 (cancerconnects.org), St. Augustine's Catholic Church, or McHarrie Pointe in Baldwinsville, NY.